Human Papillomavirus
Investigators at Yale University, Medical Department publish new data on human papillomavirus
Published in Women's Health Weekly, November 1st, 2007
According to recent research published in the journal Proceedings of the National Academy of Sciences of the United States of America, "'We used proteins with randomized transmembrane [TM) domains to explore the role of hydrophobic amino acids in mediating specific interactions between transmembrane helices. The 44-aa bovine papillomavirus E5 protein, which binds to the TM domain of the PDGF)3 receptor (PDGF beta R) was used as a scaffold to construct a library encoding small dimeric proteins with randomized, strictly hydrophobic TM domains, and proteins were selected that induced focus formation in mouse C127 cells by activating the PDGF beta R. Analysis of these proteins...
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