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Ductal Carcinoma in Situ

New findings reported from State University of New York describe advances in ductal carcinoma in situ

Published in Women's Health Weekly, December 27th, 2007

"The lack of prognostic factors in ductal carcinoma in situ (DCIS) that reliably identifies biologically aggressive tumors adversely affects optimal management. The urokinase-type plasminogen activator (uPA) system, comprised of its receptor, uPAR, and its inhibitor (PAI-1), are critical elements for tumor invasion and their expression in invasive breast cancer can predict clinical outcome," investigators in the United States report.

"Expression of the uPA system in DCIS may be relevant in defining histological subsets of DCIS with invasive potential. Localization of uPA, uPAR, and PAI-1 was investigated immunohistochemically in 60 DCIS tumors. FISH experiments were...

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