Breast Cancer Risk Factors
Studies from Duke University provide new data on breast cancer risk factors
Published in Women's Health Weekly, January 3rd, 2008
Researchers detail in 'Morphologically normal-appearing mammary epithelial cells obtained from high-risk women exhibit methylation silencing of INK4a/ARF,' new data in breast cancer. According to recent research from the United States, "P16(INK4a) has been appreciated as a key regulator of cell cycle progression and senescence. Cultured human mammary epithelial cells that lack p16(INK4a) activity have been shown to exhibit premalignant phenotypes, such as telomeric dysfunction, centrosomal dysfunction, a sustained stress response, and, most recently, a dysregulation of chromatin remodeling and DNA methylation."
"These data suggest that cells that lack p16(INK4a)...
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