Breast Cancer

Reports outline breast cancer study results from A. Buness et al

Published in Women's Health Weekly, January 10th, 2008

According to a study from Heidelberg, Germany, "In cancer, chromosomal imbalances like amplifications and deletions, or changes in epigenetic mechanisms like DNA methylation influence the transcriptional activity. These alterations are often not limited to a single gene but affect several genes of the genomic region and may be relevant for the disease status."

"For example, the ERBB2 amplicon (17q21) in breast cancer is associated with poor patient prognosis. We present a general, unsupervised method for genome-wide gene expression data to systematically detect tumor patients with chromosomal regions of distinct transcriptional activity. The method aims to find...

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Source: Women's Health Weekly (2008-01-10)

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