Cancer

New data from A. Scuto et al illuminate research in cancer

Published in Women's Health Weekly, January 17th, 2008

"RbAp48 is a WD-40 protein that plays an important role in chromatin metabolism and regulates Ras signaling. Here, we report that RbAp48 is involved in the regulation of cytoskeletal organization, a novel function," scientists in the United States report.

"First, we show that transfection of RbAP48 into Hs-578T breast cancer cells (Hs-RbAp48-hi) leads to cell size reduction, a rounded cell shape, decreased cellular protrusions, and a higher nuclear/cytoplasmic ratio. Furthermore, we observed cytoskeletal F-actin organization disruption with loss of actin stress fibers and formation of membranous F-actin rings in Hs-RbAp48-hi cells. These morphologic changes were...

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Source: Women's Health Weekly (2008-01-17)

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