Down Syndrome Genetics
Findings from University of Cambridge, Institute of Biotechnology provide new insights into Down syndrome genetics
Published in Women's Health Weekly, February 7th, 2008
Scientists discuss in 'Gene expression profiling in the adult Down syndrome brain' new findings in Down syndrome. According to recent research from Cambridge, the United Kingdom, "The mechanisms by which trisomy 21 leads to the characteristic Down syndrome (DS) phenotype are unclear. We used whole genome microarrays to characterize for the first time the transcriptome of human adult brain tissue (dorsolateral prefrontal cortex) from seven DS subjects and eight controls."
"These data were coanalyzed with a publicly available dataset from fetal DS tissue and functional profiling was performed to identify the biological processes central to DS and those that may be related...
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