Monoclonal Antibodies

Denosumab Osteoporosis Study Met Primary and All Secondary Bone Mineral Density Endpoints in a Head-to-Head Comparison with Weekly Alendronate (FOSAMAX(R))

Published in Women's Health Weekly, February 7th, 2008

Amgen (NASDAQ:AMGN) announced findings from a head-to-head, double-blind study comparing the effects of twice-yearly subcutaneous injections of denosumab versus weekly oral doses of alendronate (FOSAMAX(R)) on bone mineral density (BMD) in postmenopausal women with low bone mineral density. The study met primary and all secondary endpoints.

In this one-year, non-pivotal study, denosumab treatment achieved significantly greater BMD gains at the total hip, hip trochanter and distal radius compared with alendronate. For the primary endpoint, the relative magnitude of BMD improvement at the total hip was approximately 40 percent greater in the denosumab versus the...

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Source: Women's Health Weekly (2008-02-07)

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