Women's Health Weekly
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Breast Cancer
Researchers from INSERM detail new studies and findings in the area of breast cancer
March 13th, 2008
"The nerve growth factor (NGF)-tyrosine kinase receptor TrkA plays a critical role in various neuronal and nonneuronal cell types by regulating cell survival, differentiation, and proliferation. In breast cancer cells, TrkA stimulation results in the activation of cellular growth, but downstream signaling largely remains to be described," scientists in Paris, France report. "Here we used a proteomics-based approach to identify partners involved in TrkA signaling in breast cancer cells. Wild type and modified TrkA chimeric constructs with green fluorescent protein were transfected in MCF-7 cells, and co-immunoprecipitated proteins were separated by SDS-PAGE before...
Source: Women's Health Weekly (2008-03-13)
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