Women's Health Weekly
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Cervical Cancer
Studies conducted at Ruhr University on cervical cancer recently published
March 13th, 2008
According to recent research published in the journal BMC Cancer, "Smad4 is a tumour suppressor frequently inactivated in pancreatic and colorectal cancers. We have recently reported loss of Smad4 in every fourth carcinoma of the uterine cervix." "Smad4 transmits signals from the TGF-beta superfamily of cytokines and functions as a versatile transcriptional co-modulator. The prevailing view suggests that the tumour suppressor function of Smad4 primarily resides in its capability to mediate TGF-beta growth inhibitory responses. However, accumulating evidence indicates, that the acquisition of TGF-beta resistance and loss of Smad4 may be independent events in the...
Source: Women's Health Weekly (2008-03-13)
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