Women's Health Weekly
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Ovarian Cancer
New ovarian cancer study findings have been reported by L.M. Prentice and colleagues
March 13th, 2008
"Kisspeptins and their G-protein coupled receptor, GPR54 are required for GnRH release and have been associated with anti-metastatic tumour cell behaviour in model systems. The latter might suggest that their overexpression would be associated with a better prognosis in cancer," investigators in Vancouver, Canada report. "However, kisspeptin/GPR54 interactions (autocrine, paracrine, and/or endocrine) could also impact tumour behaviour in a negative manner. Here, for the first time, we associate the immunoreactivity of the kisspeptin/GPR54 ligand-receptor pair with favourable prognosis in a large cohort of ovarian carcinomas. Immunohistochemical analysis for kisspeptin...
Source: Women's Health Weekly (2008-03-13)
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