Women's Health Weekly
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Breast Cancer Genetics
Reports from Mount Sinai Hospital describe recent advances in breast cancer genetics
March 13th, 2008
Data detailed in 'Combined effect of CCND1 and COMT polymorphisms and increased breast cancer risk' have been presented. "Estrogens are crucial tumorigenic hormones, which impact the cell growth and proliferation during breast cancer development. Estrogens are metabolized by a series of enzymes including COMT, which converts catechol estrogens into biologically non-hazardous methoxyestrogens," scientists in Toronto, Canada report. "Several studies have also shown the relationship between estrogen and cell cycle progression through activation of CCND1 transcription. In this study, we have investigated the independent and the combined effects of commonly occurring CCND1...
Source: Women's Health Weekly (2008-03-13)
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