Women's Health Weekly
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Breast Cancer
Data on breast cancer detailed by H. Hernandezvargas and co-authors
March 20th, 2008
According to recent research from Madrid, Spain, "Although the anti-tumor effects of paclitaxel result mainly from mitotic arrest, recent evidences suggest alternative mechanisms of cytotoxicity. Cell cycle, cell death and gene expression assays were used to understand the molecular mechanisms of paclitaxel cytotoxicity in breast cancer cells." "G(2)/M cell cycle arrest and cell death coincided with the regulation of genes involved in cell death, cell cycle control, microtubule-based processes, oxidative stress, and ubiquitin-proteasome system. Induction of proteasome genes was also correlated with an accumulation of protein for proteasome subunits. Furthermore, a...
Source: Women's Health Weekly (2008-03-20)
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