Women's Health Weekly
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Breast Cancer
Research on breast cancer described by A.A. Melnikov and colleagues
March 20th, 2008
"Abnormal DNA methylation is well established for cancer cells, but a methylation-based diagnostic test is yet to be developed. one of the problems is insufficient accuracy of cancer detection in heterogeneous clinical specimens when only a single gene is analyzed. A new technique was developed to produce a multigene methylation signature in each sample, and its potential for selection of informative genes was tested using DNA from formalin-fixed, paraffin-embedded breast cancer tissues," investigators in the United States report. "Fifty-six promoters were analyzed in each of 138 clinical specimens by a microarray-based modification of the previously developed...
Source: Women's Health Weekly (2008-03-20)
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