Women's Health Weekly
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Breast Cancer
Studies from Hospital for Sick Children provide new data on breast cancer
March 20th, 2008
According to recent research from Toronto, Canada, "Members of the ATP-binding cassette (ABC) efflux transporter family, including P-glycoprotein (PGP), the multidrug resistance-associated proteins (MRPs) and the breast cancer resistance protein (BCRP) have been shown to be highly expressed in the human placenta. Recent Studies documented that the oral hypoglycemic glyburide does not cross the human placenta to an appreciable extent." "Furthermore, the trans-placental transfer of glyburide has been shown not to be affected by either the presence of PGP inhibitor, verapamil or MRP inhibitor, indomethacin, Therefore, our objective was to identify other human placental ABC...
Source: Women's Health Weekly (2008-03-20)
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