Women's Health Weekly
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Breast Cancer
Data on breast cancer discussed by researchers at McGill University
March 27th, 2008
"Elevated expression and activation of the focal adhesion kinase (FAK) occurs in a large proportion of human breast cancers. Although several studies have implicated FAK as an important signaling molecule in cell culture systems, evidence supporting a role for FAK in mammary tumor progression is lacking," researchers in Montreal, Canada report. "To directly assess the role of FAK in this process, we have used the Cre/loxP recombination system to disrupt FAK function in the mammary epithelium of a transgenic model of breast cancer. Using this approach, we demonstrate that FAK expression is required for the transition of premalignant hyperplasias to carcinomas and their...
Source: Women's Health Weekly (2008-03-27)
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