Women's Health Weekly
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Breast Cancer
New breast cancer study findings have been reported by R. Colomer and colleagues
March 27th, 2008
In this recent report, researchers in Madrid, Spain conducted a study "To evaluate the efficacy of treatment with the aromatase inhibitor letrozole in breast cancer patients segregated with respect to DNA polymorphisms of the aromatase gene CYP19. Postmenopausal patients (n = 67) with hormone receptor-positive metastatic breast cancer were treated with the aromatase inhibitor letrozole." "PCR allelic discrimination was used to examine three single-nucleotide polymorphisms (SNP) in DNA obtained from breast carcinoma tissue. Two SNPs analyzed (rs10046 and rs4646) were located in the 3' untranslated region and one (rs727479) was in the intron of the aromatase CYP19 gene....
Source: Women's Health Weekly (2008-03-27)
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