Women's Health Weekly
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Breast Cancer
Reports on breast cancer findings from C. Justenhoven and co-researchers provide new insights
April 3rd, 2008
According to a study from Stuttgart, Germany, "Polymorphisms within the estrogen metabolic pathway are prime candidates for a possible association with breast cancer risk. We investigated 11 genes encoding key proteins of this pathway for their potential contribution to breast cancer risk." "Of these CYP17A1, CYP19A1, EPHX1, HSD17B1, SRD5A2, and PPARG2 participate in biosynthesis, CYP1A1, CYP1B1, COMT, GSTP1, and SOD2 in catabolism and detoxification. We performed a population-based case-control study with 688 incident breast cancer cases and 724 controls from Germany and genotyped 18 polymorphisms by matrix assisted laser desorption/ionization time-of-flight mass...
Source: Women's Health Weekly (2008-04-03)
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