Women's Health Weekly
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Breast Cancer
Research in the area of breast cancer reported from M.M. Gaudet and colleagues
April 3rd, 2008
"Background p53 participates in cell cycle control, programmed cell death/apoptosis, and DNA repair, all pathways involved in carcinogenesis. TP53 variants may influence p53 function," researchers in the United States report. " We evaluated whether three well-characterized TP53 variants-Ex4 + 119 C> G (rs#1042522, Arg72Pro), IVS6 + 62 A> G (rs#1625895), and an IVS3 16 bp insertion/ deletion (INDEL; rs#17878362)-were associated with breast cancer risk in a population-based case-control study. Genotypes and haplotypes were determined using long-range PCR in a sample of 578 cases and 390 controls. For the Ex4 + 19 C> G SNP (rs1042522), women with the...
Source: Women's Health Weekly (2008-04-03)
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