Women's Health Weekly
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Breast Cancer
Research on breast cancer published by scientists at University of California
April 3rd, 2008
"TRX3 is a transcription factor of the T-box gene family. Mutations in the TBX3 gene can cause hypoplastic or absent mammary glands," scientists in the United States report. "Previous studies have shown that TRX3 might be associated with breast cancer. Here, we show that TRX3 is overexpressed in malignant cells of primary breast cancer tissues by immunohistochemistry. TBX3 interacts with histone deacetylases (HDAC) 1, 2, 3, and 5. TBX3 interacts with HDAC1, 2, and 3 via two distinct binding sites. However, deletion of the repression domain (amino acids 566-624) of TRX3 completely abolishes its interaction with HDAC5. Endogenous TRX3 and HDACs interaction and...
Source: Women's Health Weekly (2008-04-03)
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