Women's Health Weekly
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Breast Cancer
Studies from Ohio State University have provided new information about breast cancer
April 3rd, 2008
According to recent research published in the journal Cancer Research, "We developed stromal- and epithelial-specific cre-transgenic mice to directly visualize epithelial-mesenchymal transition (EMT) during cancer progression in vivo." "Using three different oncogene-driven mouse mammary tumor models and cell-fate mapping strategies, we show in vivo evidence for the existence of EMT in breast cancer and show that myc can specifically elicit this process. Hierarchical cluster analysis of genome-wide loss of heterozygosity reveals that the incidence of EMT in invasive human breast carcinomas is rare, but when it occurs it is associated with the amplification of...
Source: Women's Health Weekly (2008-04-03)
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