Women's Health Weekly
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Breast Cancer
New findings in breast cancer described from Harvard University
April 10th, 2008
According to recent research from the United States, "Cancers may arise from rare self-renewing tumor- initiating cells (T-IC). However, how T-IC self renewal, multipotent differentiation, and tumorigenicity are maintained remains obscure." "Because miRNAs can regulate cell-fate decisions, we compared miRNA expression in self-renewing and differentiated cells from breast cancer lines and in breast T-IC (BT-IC) and non-BT-IC from 1 degrees breast cancers. Iet-7 miRNAs were markedly reduced in BT-IC and increased with differentiation. Infecting BT-IC with Iet-7-lentivirus reduced proliferation, mammosphere formation, and the proportion of undifferentiated cells in vitro...
Source: Women's Health Weekly (2008-04-10)
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