Women's Health Weekly
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Breast Cancer
Research from University College yields new findings on breast cancer
April 10th, 2008
According to a study from London, the United Kingdom, "Brn-3b transcription factor enhances proliferation of neuroblastoma (NB) and breast cancer cell lines in vitro and increases the rate and size of in vivo tumour growth, whereas reducing Brn-3b slows growth, both in vitro and in vivo. Brn-3b is elevated in > 65% of breast cancer biopsies, and here we demonstrate that Brn-3b is also elevated in NB tumours." "We show a significant correlation between Brn-3b and cyclin D1 (CD1) in breast cancers and NB tumours and cell lines. Brn-3b directly transactivates the CD1 promoter in co-transfection experiments, whereas electrophoretic mobility shift assay and chromatin...
Source: Women's Health Weekly (2008-04-10)
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