Women's Health Weekly
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Breast Cancer
Study data from Columbia University update understanding of breast cancer
April 10th, 2008
According to recent research from the United States, "Basal-like breast cancer (BBC) is a subtype of breast cancer with poor prognosis(1 - 3). Inherited mutations of BRCA1, a cancer susceptibility gene involved in double-strand DNA break (DSB) repair, lead to breast cancers that are nearly always of the BBC subtype(3 - 5); however, the precise molecular lesions and oncogenic consequences of BRCA1 dysfunction are poorly understood." "Here we show that heterozygous inactivation of the tumor suppressor gene Pten leads to the formation of basal-like mammary tumors in mice, and that loss of PTEN expression is significantly associated with the BBC subtype in human sporadic...
Source: Women's Health Weekly (2008-04-10)
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