Women's Health Weekly
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Cancer
Data on cancer reported by researchers at Southern Illinois University, Medical Department
April 10th, 2008
"The fatty acid synthase (FAS) gene is significantly up-regulated in various types of cancers, and blocking the FAS expression results in apoptosis of tumor cells. Therefore, FAS is considered to be an attractive target for anticancer therapy," scientists in the United States report. "However, the molecular mechanism by which the FAS gene is up-regulated in tumor cells is poorly understood. We found that FAS was significantly up-regulated by hypoxia, which was also accompanied by reactive oxygen species (ROS) generation in human breast cancer cell lines. The FAS expression was also activated by H2O2, whereas N-acetyl-L-cystein, a ROS inhibitor, suppressed the...
Source: Women's Health Weekly (2008-04-10)
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