Women's Health Weekly
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Cancer
New cancer findings from Washington University, Medical Department described
April 10th, 2008
According to recent research published in the journal Gynecologic Oncology, "We ascertained a large kindred with an excess of Lynch syndrome-associated cancers. Our objective was to determine if a defect in one of the DNA mismatch repair (DMMR) genes was the probable cause of cancer susceptibility as microsatellite instability (MSI) and immunohistochemical (IHC) analysis of the probands' tumors did not provide a clear indication." "A detailed history and review of medical records was undertaken to construct a four-generation pedigree. Blood samples were obtained for analysis of germline DNA. Polymorphic repeats from the MLH1, MSH2, MSH6, and PMS2 loci were...
Source: Women's Health Weekly (2008-04-10)
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