Women's Health Weekly
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Cancer
New cancer research has been reported by scientists at University of Yamanashi
April 10th, 2008
"We report here that human MFGE8 encoding milk fat globule-EGF factor 8 protein (MFG-E8), also termed 46 kDa breast epithelial antigen and lactadherin, is transcriptionally activated by p63, or TP63, a p53 (TP53) family protein frequently overexpressed in head-and-neck squamous cell carcinomas, mammary carcinomas and so on. Despite that human MFG-E8 was originally identified as a breast cancer marker, and has recently been reported to provide peptides for cancer immunotherapy, its transcriptional control remains an open question," scientists in Yamanashi, Japan report. "Observations in immunohistochemical analyses, a tetracycline-induced p63 expression system and...
Source: Women's Health Weekly (2008-04-10)
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