Women's Health Weekly
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DNA Research
Study findings on DNA research are outlined in reports from F. Daboussi and colleagues
April 10th, 2008
According to a study from France, "Faithful genome transmission requires a network of pathways coordinating DNA replication to DNA repair and recombination. Here, we used molecular combing to measure the impact of homologous recombination (HR) on the velocity of DNA replication forks." "We used three hamster cell lines defective in HR either by overexpression of a RAD51 dominant-negative form, or by a defect in the RAD51 paralogue XRCC2 or the breast tumor suppressor BRCA2. Irrespectively of the type or extent of HR alteration, all three cell lines exhibited a similar reduction in the rate of replication-fork progression, associated with an increase in the density of...
Source: Women's Health Weekly (2008-04-10)
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