Women's Health Weekly
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Breast Cancer
Findings in breast cancer reported from University of Pennsylvania
April 17th, 2008
According to recent research from the United States, "Parvin-beta is a focal adhesion protein downregullated in human breast cancer cells. Loss of Parvin-beta contributes to increased integrin-linked kinase activity, cell-matrix adhesion, and invasion through the extracellular matrix in vitro." "The effect of ectopic Parvin-P expression on the transcriptional profile of MDA-MB-231 breast cancer cells, which normally do not express Parvin-beta, was evaluated. Particular emphasis was placed upon propagating MDA-MB-231 breast cancer cells in three-dimensional culture matrices. Interestingly, Parvin-beta reexpression in MDA-MB-231 cells increased the mRNA expression, serine...
Source: Women's Health Weekly (2008-04-17)
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