Women's Health Weekly
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Gene Therapy
Researchers from University of California publish findings in gene therapy
April 17th, 2008
"Mechanisms underlying global changes in gene expression during tumour progression are poorly understood. SATB1 is a genome organizer that tethers multiple genomic loci and recruits chromatin- remodelling enzymes to regulate chromatin structure and gene expression," scientists writing in the journal Nature report. "Here we show that SATB1 is expressed by aggressive breast cancer cells and its expression level has high prognostic significance ( P< 0.0001), independent of lymph- node status. RNA- interference- mediated knockdown of SATB1 in highly aggressive ( MDA- MB- 231) cancer cells altered the expression of >1,000 genes, reversing tumorigenesis by...
Source: Women's Health Weekly (2008-04-17)
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