Women's Health Weekly
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Rhabdoid Tumors
Kyoto Prefectural University reports research in rhabdoid tumors
April 17th, 2008
"Malignant rhabdoid tumor (MRT) is an early childhood cancer with poor prognosis. Trastuzumab, a humanized monoclonal antibody against human epidermal growth factor receptor-2 (HER-2), has been shown to be effective against breast cancer and other cancers," investigators in Kyoto, Japan report. "We investigated the effect of trastuzumab on MRT cell lines. We examined expression of HER-2 on four MRT cell lines and two tumor tissues by indirect immunofluorescence, flow cytometry, and immunohistochemistry. The effect of trastuzumab against MRT cells was examined by cell growth assay. To observe the antibody-dependent cellular cytotoxicity of effector cells, we examined the...
Source: Women's Health Weekly (2008-04-17)
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