Women's Health Weekly
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Breast Cancer
Findings from M.C.U. Cheang and co-researchers advance knowledge in breast cancer
April 24th, 2008
"Basal-like breast cancer is associated with high grade, poor prognosis, and younger patient age. Clinically, a triple-negative phenotype definition [estrogen receptor, progesterone receptor, and human epidermal growth factor receptor (HER)-2, all negative] is commonly used to identify such cases," scientists in Vancouver, Canada report. "EGFR and cytokeratin 5/6 are readily available positive markers of basal-like breast cancer applicable to standard pathology specimens. This study directly compares the prognostic significance between three- and five-biomarker surrogate panels to define intrinsic breast cancer subtypes, using a large clinically annotated series of...
Source: Women's Health Weekly (2008-04-24)
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