Women's Health Weekly
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Breast Cancer
Research from E.L. Salazar et al has provided new information about breast cancer
April 24th, 2008
According to recent research from Mexico, "We have studied the modulation and differential sensitivity of the estrogen receptor (ER) in breast cancer in the presence of protecting or modifying agents of disulfide bonds and sulfhydryl groups present in the ER steroid-binding domain." "Protecting agents such as mercaptoethanol and dithiotreitol increased the [H-3]estradiol binding to ER by 25% and 50%, respectively. Modifying agents such as p-chloromercuribenzensulfonate decreased the [H-3]estradiol binding by 70% and this was nearly completely abolished by N-ethylmalcimide (94%)," wrote E.L. Salazar and colleagues. The researchers concluded: "These...
Source: Women's Health Weekly (2008-04-24)
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