Women's Health Weekly
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Breast Cancer
Research from Queen's University in breast cancer provides new insights
April 24th, 2008
According to recent research from Kingston, Canada, "Decision-making regarding early closure and reporting of clinical trial results became a topic of intense debate following the reporting of the MA.17 adjuvant endocrine therapy trial. This trial was terminated at the first planned interim analysis when a highly significant improvement in disease free survival (DFS) was found." "It has been suggested that the criterion for early stopping be made stricter when DFS is the primary study endpoint by ensuring that the targeted effect size is excluded. Our purpose is to examine this approach and to determine whether applying such a criterion would have affected the decision...
Source: Women's Health Weekly (2008-04-24)
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