Women's Health Weekly
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Breast Cancer
Research results from M. Smollich and colleagues update understanding of breast cancer
April 24th, 2008
"Tumour hypoxia, being widespread in solid tumours, is related to an increased risk of invasion and metastasis as well as to resistance to chemotherapy and radiotherapy. Hypoxia-inducible factor-1 alpha (HIF-1 alpha) has emerged as the key regulator of the cellular response to hypoxia," scientists writing in the journal Breast Cancer Research and Treatment report. "In primary breast cancers, HIF-1 alpha is overexpressed, and high levels of HIF-1 alpha predict for early relapse and increased metastasis. The endothelin (ET) axis, comprising the peptides ET-1, -2, -3 and their receptors A (ETAR) and B (ETBR), is another regulatory system of major relevance in human...
Source: Women's Health Weekly (2008-04-24)
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