Endometrial Hyperplasia

New endometrial hyperplasia study results reported from University of Texas

Published in Women's Health Weekly, May 1st, 2008

"PTEN mutations have been implicated in the development of endometrial hyperplasia and subsequent cancer. Peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonists have demonstrated antineoplastic and chemopreventive effects," researchers in the United States report.

"The purpose of this study was to evaluate the effects of the PPAR-gamma agonist rosiglitazone on both PTEN wild type and PTEN null cell lines and in the PTEN heterozygote((+/-)) murine model. Hec-1-A (PTEN wild type) and Ishikawa (PTEN null) cells were treated with rosiglitazone. Thirty-five female PTEN+/- mice were genotyped and placed into one of four groups for treatment for 18 weeks: A)...

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Source: Women's Health Weekly (2008-05-01)

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