Neutropenia

Research reports from G. Vonminckwitz and co-authors provide new insights into neutropenia

Published in Women's Health Weekly, May 1st, 2008

According to a study from Germany, "TAC (docetaxel/doxorubicin/cyclophosphamide) is associated with high incidences of grade 4 neutropenia and febrile neutropenia (FN). This analysis compared the efficacies of four regimens for primary prophylaxis of FN and related toxic effects in breast cancer patients receiving neoadjuvant TAC."

"Patients with stage T2-T4 primary breast cancer were scheduled to receive 6-8 cycles of TAC. Primary prophylaxis was: ciprofloxacin 500 mg orally twice daily on days 5-14 (n = 253 patients; 1478 cycles), daily granulocyte colony-stimulating factor (G-CSF) (filgrastim 5 mu g/kg/day or lenograstim 150 mu g/m(2)/day) on days 5-10 (n = 377; 2400...

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Source: Women's Health Weekly (2008-05-01)

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