Women's Health Weekly
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Breast Cancer
Findings from Johns Hopkins University, Medical Department provide new insights into breast cancer
May 1st, 2008
According to a study from the United States, "Twist is a basic helix loop helix protein that plays a role both in human development and in cancer biogenesis. While characterizing the effects of Twist on breast epithelial cell transformation, we identified E-cadherin as a target gene that is down-regulated by Twist." "In this study, we demonstrate that Twist can transcriptionally repress E-cadherin in breast cancer cells. Using transient promoter assays, we show that Twist can down-regulate E-cadherin promoter activity by up to two folds. This is further supported by immunoblot analyses which indicates that over-expression of Twist decreases E-cadherin protein levels in...
Source: Women's Health Weekly (2008-05-01)
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