Women's Health Weekly
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Breast Cancer
Recent findings from Northwestern University highlight research in breast cancer
May 1st, 2008
"TGFBR1*6A is a common hypomorphic variant of the type 1 transforming growth factor 0 receptor (TGFBR1), which has been associated with increased cancer risk in some studies. Although TGFBB1*6A is capable of switching TGF-beta growth-inhibitory signals into growth-stimulatory signals when stably transfected into MCF-7 breast cancer cells, the biological effects of TGFBB1*6A are largely unknown," investigators in the United States report. "To broadly explore the potential oncogenic properties of TGFBR1*6A, we assessed its effects on NIH-3T3 cells as well as its effect on the migration and invasion of MCF-7 cells. We found that TGFBR1*6A has decreased oncogenic properties...
Source: Women's Health Weekly (2008-05-01)
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