Women's Health Weekly
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Breast Cancer
Reports summarize breast cancer research from Nagoya University, Medical Department
May 1st, 2008
"Girdin (girders of actin filaments) is a novel actin-binding Akt substrate that plays an important role in actin organization and Akt-dependent cell motility in fibroblasts. Here, we find that Girdin is expressed in a variety of cancer cell lines, including the breast cancer cell tine MDA-MB-231, and is phosphorylated by the stimulation of insulin-like growth factor (IGF-I)," investigators in Nagoya, Japan report. "In vitro migration and invasion assays showed that Girdin is required for the IGF-I-dependent cell movement of MDA-MB-231 cells. Short hairpin interfering RNA directed against Girdin markedly inhibited the metastasis of s.c. transplanted MDA-MB-231 cells in...
Source: Women's Health Weekly (2008-05-01)
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