Women's Health Weekly
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Breast Cancer
Research by H. Xing and colleagues in breast cancer provides new insights
May 1st, 2008
According to recent research from Wuhan, People's Republic of China, "Although multiple mechanisms have been implicated in chemoresistance, recent evidence has suggested that the attachment of cells to extracellular matrix proteins such as fibronectin (FN) may mediate the signals that participate in cell survival and resistance to apoptosis. We established previously that human ovarian cancer cells and breast cancer cells adhering to FN acquire a survival advantage through activation of the PI3-kinase/Akt2 pathway." "However, the mechanism by which Akt2 regulates chemoresistance in adherent cells is unknown. In the present study, we have investigated the role of the...
Source: Women's Health Weekly (2008-05-01)
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