Women's Health Weekly
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Breast Cancer
Research from University of Porto, Medical Department in breast cancer provides new insights
May 1st, 2008
"In previous Studies, we found that progesterone was able to induce the expression of platelet-derived growth factor (PDGF) in human breast cancer MCF7 cells. Knowing that imatinib rnesylate targets PDGF receptor tyrosine kinase activity, the aim of the present study was to examine the effects of imatinib on progesterone-treated MCF7 cells," scientists in Oporto, Portugal report. "Expression of phosphorylated (activated) platelet-derived growth factor receptor-alpha (PDGFR alpha) was detected in MCF7 cells. Interestingly, phosphorylated-PDGFR alpha expression was significantly downregulated by imatinib. The effects of imatinib oil cell growth, apoptosis and migration...
Source: Women's Health Weekly (2008-05-01)
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