Women's Health Weekly
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Breast Cancer
Research results from University of Toronto, Medical Department update knowledge of breast cancer
May 1st, 2008
According to recent research published in the journal Annals of Oncology, "Although disease-free survival (DFS) is accepted as a valid end point in adjuvant breast cancer trials, improvement in 2-year DFS has never been formally established as an adequate correlate for 5-year overall survival (OS). We set out to ascertain if changes in 2-year DFS can be used to accurately predict 5-year OS changes." "We conducted a systematic Medline search (1966-2006) for randomized adjuvant breast cancer trials of > 100 patients per arm with 2-year DFS and 5-year OS data. A univariate regression model weighted by trial sample size was constructed to determine whether 2-year...
Source: Women's Health Weekly (2008-05-01)
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