Women's Health Weekly
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Breast Cancer
Findings from Tohoku University provide new insights into breast cancer
May 8th, 2008
According to recent research from Sendai, Japan, "TP53 mutations are a poor prognostic factor in breast cancers. The present study sets out to identify the gene set that determines the expression signature of the TP53 status (TP53 signature) and to correlate it with clinical outcome." "Using comprehensive expression analysis and DNA sequencing of the TP53 gene in 38 Japanese breast cancer patients, a gene set from differentially expressed genes was isolated, depending on the TP53 status. As independent external datasets, two published datasets were introduced for validation of TP53 status predictions (251 Swedish samples) and survival analysis (both the Swedish and 295...
Source: Women's Health Weekly (2008-05-08)
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