Cancer
Scientists at University of British Columbia target cancer
Published in Women's Health Weekly, May 8th, 2008
New investigation results, 'Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer,' are detailed in a study published in Journal of Cell Science. According to a study from Vancouver, Canada, "Inactivation of the transcription factor and tumor suppressor p53, and overexpression or mutational activation of PIK3CA, which encodes the p110alpha catalytic subunit of phosphatidylinositol-3-kinase (PI3K), are two of the most common deleterious genomic changes in cancer, including in ovarian carcinomas. We investigated molecular mechanisms underlying interactions between these two mediators and their possible roles in ovarian...
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