Women's Health Weekly
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Breast Cancer
New breast cancer study findings have been published by scientists at University of Tokyo
May 8th, 2008
According to a study from Tokyo, Japan, "ErbB2-negative breast tumors represent a significant therapeutic hurdle because of a lack of effective molecular targets. Although NOTCH proteins are known to be involved in mammary tumorigenesis, the functional significance of these proteins in ErbB2-negative breast tumors is not clear." "In the present study, we examined the expression of activated NOTCH receptors in human breast cancer cell lines, including ErbB2-negative and ErbB2-positive cell lines. Activated NOTCH1 and NOTCH3 proteins generated by gamma-secretase were detected in most of the cell lines tested, and both proteins activated CSL-mediated transcription....
Source: Women's Health Weekly (2008-05-08)
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