Women's Health Weekly
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Breast Cancer
New findings from M.P.V. Shekhar and co-authors describe advances in breast cancer
May 8th, 2008
"Mutations in beta-catenin or other Writ pathway components that cause beta-catenin accumulation occur rarely in breast cancer. However, there is some evidence of beta-catenin protein accumulation in a subset of breast tumors," investigators in the United States report. "We have recently shown that Rad6B, an ubiquitin-conjugating enzyme, is a transcriptional target of beta-catenin/TCF. Here, we show that forced Rad6B overexpression in MCF10A breast cells induces beta-catenin accumulation, which despite being ubiquitinated is stable and transcriptionally active. A similar relationship between Rad6B, beta-catenin ubiquitination, and transcriptional activity was found in...
Source: Women's Health Weekly (2008-05-08)
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