Women's Health Weekly
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Breast Cancer
Studies from C. Williams and co-researchers yield new data on breast cancer
May 8th, 2008
"Transcriptional effects of estrogen result from its activation of two estrogen receptor (ER) isoforms; ER alpha that drives proliferation and ER beta that is antiproliferative. Expression of ERb in xenograft tumors from the T47D breast cancer cell line reduces tumor growth and angiogenesis," scientists in Huddinge, Sweden report. "If ERb can halt tumor growth, its introduction into cancers may be a novel therapeutic approach to the treatment of estrogen-responsive cancers. To assess the complete impact of ER beta on transcription, we have made a full transcriptome analysis of ER alpha- and ER beta-mediated gene regulation in T47D cell line with Tet-Off regulated ERb...
Source: Women's Health Weekly (2008-05-08)
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