Women's Health Weekly
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Cancer
Studies from C. Heinlein and colleagues provide new data on cancer
May 8th, 2008
According to recent research from Hamburg, Germany, "In human breast cancer, mutations in the p53 gene are associated with poor prognosis. However, analysis of patient data so far did not clarify, whether missense point mutations in the p53 gene, in addition to causing loss of wild-type p53 function, also confer a gain of function phenotype to the encoded mutant p53." "As heterogeneity of patient material and data might obscure a clear answer, we studied the effects of a coexpressed mutant p53(R270H) in transgenic mice in which SV40 early proteins initiate the development of mammary adenocarcinoma (WAP-T mice). In such tumors the endogenous wild-type p53 is functionally...
Source: Women's Health Weekly (2008-05-08)
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