Women's Health Weekly
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Cancer
Studies from Georgetown University reveal new findings on cancer
May 8th, 2008
"BRCA1 can regulate estrogen receptor-alpha (ER alpha) activity. This study tested the hypotheses that Brca1 loss in mammary epithelium alters the estrogenic growth response and that exposure to increased estrogen or ER alpha collaborates with Brca1 deficiency to accelerate preneoplasia and cancer development," investigators in the United States report. "Longer ductal extension was found in mammary glands of Brca1(f/f;MMTV-Cre) mice during puberty as compared to wild-type mice. Terminal end bud differentiation was impaired in Brca1 mutant mice with preservation of prolactin-induced alveolar differentiation. Exogenous estrogen stimulated an abnormal sustained increase in...
Source: Women's Health Weekly (2008-05-08)
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