Women's Health Weekly
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Apoptosis
Recent findings from RIKEN highlight research in apoptosis
May 15th, 2008
"The activating transcription factor, ATF-2, is a target of p38 and JNK that are involved in stress-induced apoptosis. Heterozygous Atf-2 mutant ( Atf-2(+/-)) mice are highly prone to mammary tumors," investigators in Tsukuba, Japan report. "The apoptosis-regulated gene GADD45 alpha and the breast cancer suppressor gene Maspin, both of which are known to be p53 target genes, are downregulated in the mammary tumors arisen in Atf-2(+/-) mice. Here, we have analysed how ATF-2 controls the transcription of GADD45a and Maspin. ATF-2 and p53 independently activate the GADD45a transcription. ATF-2 does not directly bind to the GADD45a promoter; instead, it is recruited via Oct-1...
Source: Women's Health Weekly (2008-05-15)
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